经常发生的心膜炎. 随着科尔奇辛的使用,得到了缓解
J Guindo1, A Rodriguez de la Serna, J Ramió
1Department of Cardiology, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Spain.
Circulation
|October 1, 1990
概括
在多次复发的患者中,素有效地预防心周炎的复发. 这种治疗允许停止普得尼松治疗,并保持无症状期,这表明了胆固醇.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
背景情况:
- 心膜炎的复发是一个重大的临床挑战.
- 目前治疗复发性心膜炎的方法通常涉及免疫抑制剂或手术.
- 患者经常经历多次复发尽管标准疗法.
研究的目的:
- 为了评估菌素在预防心膜炎复发中的有效性.
- 评估科尔奇辛在耐火性或复发性心膜炎患者中的作用.
主要方法:
- 这是一项开放的前性研究,涉及9名有至少3次心膜炎复发病史的患者.
- 患者接受了胆固醇 (1毫克/天) 以预防复发.
- 统计分析使用了一种对对比设计 (学生的t测试).
主要成果:
- 所有9名患者都对菌素治疗做出了良好的反应.
- 在2-6周内,所有患者都成功地停止了普雷尼松的治疗.
- 在平均随访时间为24.3个月 (范围为10-54个月) 期间,没有观察到复发.
- 在没有症状的时期中,有统计学显著的改善 (p < 0.002).
结论:
- 科尔奇辛似乎是预防心膜炎复发的有希望的药物.
- 这些发现表明,素可以促进其他药物的戒断,如普得尼松.
- 需要更大的双盲研究来证实这些结果.
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