虚弱与老年患者的短期结果独立相关,这些老年患者非ST段升高心肌梗塞
Niklas Ekerstad1, Eva Swahn, Magnus Janzon
1Center for Medical Technology Assessment/IMH, Linköping University, Sandbäcksgatan 7, 58183 Linköping, Sweden. niklas.ekerstad@liu.se
Circulation
|November 9, 2011
概括
脆弱性显著增加了短期死亡率和老年患者因非ST段升高心肌梗塞住院的不良结果. 评估脆弱性对于预测这些脆弱心血管患者的风险至关重要.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 临床医学 临床医学
背景情况:
- 老年心血管疾病患者需要准确的生物年龄和风险评估.
- 脆弱,表明脆弱性和降低生理储备,是一个新兴的临床概念.
- 这项研究调查了老年肌肉梗塞患者的短期结果的虚弱的预测价值.
研究的目的:
- 为了确定脆弱性是否预测非ST段升高心肌梗塞的老年患者的短期不良结果.
- 评估脆弱与死亡率和其他重大不良事件的独立关联.
- 探索脆弱性和并发症在风险预测方面的联合实用性.
主要方法:
- 在3个中心对307名75岁以上的非ST段升高心肌梗塞患者进行前性队列研究.
- 使用加拿大健康与衰老研究临床脆弱度量表评估的脆弱性.
- 使用冠状动脉疾病特异指数量化风险;通过多重逻辑回归进行统计分析.
主要成果:
- 近一半 (48.5%) 的患者被确定为脆弱.
- 虚弱与主要复合结果 (死亡,心脏复发,再血管,住院,出血,中风,1个月内透析) 的风险增加2.2倍独立相关.
- 虚弱显著预测住院死亡率 (OR 4.6) 和1个月死亡率 (OR 4.7).
结论:
- 虚弱是老年肌肉梗塞患者死亡率和不良结果的强有力的独立预测因素.
- 它与长时间的住院护理和复合不良事件结果有关.
- 结合脆弱性和并发症评估,为复杂心血管患者提供了全面的风险预测策略.
相关概念视频
01:15Drug Dosing: Geriatric Patients
402
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
402
01:21Myocarditis I: Introduction
647
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
647
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
961
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
961
01:30Acute Coronary Syndrome III: Diagnostic Studies
502
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
502
01:27Heart Failure I: Introduction
2.1K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
2.1K
01:30Development of Human Microbiota
73
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from...
73