从Apolipoprotein B100 (ApoBDS-1) 鉴定出一种与危险相关的,该会触发先天性益风性反应
Daniel F J Ketelhuth1, Francisco J O Rios, Yajuan Wang
1Center for Molecular Medicine, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
Circulation
|November 9, 2011
概括
研究人员从低密度脂蛋白中发现了一种新的,ApoB100危险相关信号1 (ApoBDS-1). 这种可以通过激活免疫细胞和信号通路来促进动脉样硬化的炎症.
科学领域:
- 心血管生物学 心血管生物学
- 免疫学 免疫学 免疫学
- 分子医学是分子医学.
背景情况:
- 低密度脂蛋白 (LDL) 颗粒与动脉样硬化病原发生有关.
- 在LDL中的特定炎症成分仍然不完全理解.
- 对Apolipoprotein B100 (ApoB100) 的免疫反应与动脉样硬化的进展有关.
研究的目的:
- 为了研究阿波利波蛋白B100 (ApoB100) 衍生在动脉样硬化中的促炎活性.
- 为了确定有助于动脉样硬化的炎症过程的特定ApoB100.
主要方法:
- 对ApoB100库进行选,以识别生物活性.
- 评估已识别的的生物活性对细胞因子生产 (互乐金-8,CCL2,互乐金-6) 和信号通路 (MAPK,) 的影响.
- 使用免疫试验对状腺斑块进行ex vivo刺激,并分析动脉样硬化病变中的存在.
主要成果:
- 鉴定了一种新型,ApoB100危险相关信号1 (ApoBDS-1),具有序列特定的促炎活性.
- ApoBDS-1通过激活先天免疫细胞中的MAPK和信号来刺激介素-8,CCL2和介素-6的产生.
- ApoBDS-1 增强 carotid 斑块中的互白素-8 和前列腺素 E2 的释放,并且存在于动脉样硬化病变中.
结论:
- ApoBDS-1是一种以前未被识别的,具有显著的炎症促进性.
- ApoBDS-1有助于LDL在动脉样硬化中的促进疾病的炎症作用.
- 这一发现为了解和治疗动脉样硬化提供了潜在的新目标.
相关概念视频
Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
The Intrinsic Apoptotic Pathway
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
Inflammation
Overview
Receptor-mediated Endocytosis
Overview
The Extrinsic Apoptotic Pathway
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
Atherosclerosis I: Introduction
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

