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let-7微RNA与Lin28的相互作用的分子基础

Yunsun Nam1, Casandra Chen, Richard I Gregory

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

Cell
|November 15, 2011
PubMed
概括

林28蛋白特别通过与let-7前体结合来抑制let-7微RNA (miRNA) 的产生. 它的结构揭示了它如何识别多样化的let-7家族成员,解释了它在基因表达中的调节作用.

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