前庭动导管切除与手术切除治疗 (FAST):一个双中心随机临床试验
Lucas V A Boersma1, Manuel Castella, Wimjan van Boven
1Cardiology Department, St. Antonius Hospital, PO 2500, Nieuwegein, Netherlands. l.boersma@antoniusziekenhuis.nl
Circulation
|November 16, 2011
概括
外科切除 (SA) 比导管切除 (CA) 更有效治疗抗药性心房动,实现更好的心律失常. 然而,SA与CA相比,具有更高的程序并发症风险.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 最少侵入性的手术
背景情况:
- 导管切除 (CA) 和微创手术切除 (SA) 是药物耐药心房的已知疗法.
- 这项研究提出了第一个随机临床试验,比较CA和SA的疗效和安全性.
研究的目的:
- 为了比较导管切除 (CA) 与最小侵入性手术切除 (SA) 的疗效和安全性,在患有抗药性心房的患者中.
- 为了评估没有左心房律乱的速度和12个月后不良事件的发生率.
主要方法:
- 一项随机临床试验,涉及124名患有抗心律失常药物耐药性心房的患者.
- 患者被随机分配到CA (n=63) 或SA (n=61).
- 随访包括6个月和12个月的ECG和7天的霍尔特记录.
主要成果:
- 手术切除 (SA) 在12个月后 (P=0.0022) 与导管切除 (CA) (36.5%) 相比,实现了显著更高的左心房失常率 (65.6%).
- 显著不良事件的发生率在SA组 (34.4%) 高于CA组 (15.9%) (P=0.027).
- 在SA中出现的不良事件包括肺胸,严重出血和起器需求.
结论:
- 在特定患者群体中,微创性外科切除 (SA) 优于导管切除 (CA) 在实现长期摆脱心房动方面.
- 尽管SA的疗效优越,但与CA相比,SA与程序并发症的发生率明显高.
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