前庭动病理生理学:对管理的影响.
Yu-ki Iwasaki1, Kunihiro Nishida, Takeshi Kato
1Department of Medicine and Research Center, Montreal Heart Institute, Quebec, Canada.
Circulation
|November 16, 2011
概括
心房动 (AF) 是一种常见的心律障碍,特别是在老年人中. 了解它的基本机制是开发新治疗方法的关键,用于节律控制,节律控制,切除和预防血栓.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 翻译医学是一种翻译医学.
背景情况:
- 心房动 (AF) 是最常见的持续心律失常,对患病率和死亡率有显著的贡献,特别是在老年人群中.
- 由于人口向老年人口的变化,AF的患病率正在增加.
- 最近的进展迅速提高了我们对AF发生和持久性背后的基本机制的理解.
研究的目的:
- 在多个层面上对心房动的基本病理生理学进行全面的审查.
- 探索AF病理生理学对其临床管理的影响,包括药物治疗,切除和血栓塞栓预防.
- 讨论以AF机制为重点的翻译研究的未来方向.
主要方法:
- 关于AF病理生理学的基础科学文献的综述.
- 分析组织层面的机制,离子通道异常,重塑过程和自主/解剖因素.
- 检查基本机制与临床表现之间的关系.
- 讨论对治疗策略的影响.
主要成果:
- AF病理生理学涉及组织,细胞和分子层面的复杂相互作用,包括重新进入,宫外脉冲形成和电气/结构重塑.
- 自主性,解剖学和心房-心室相互作用在AF中起着重要作用.
- 基本机制直接告知节律控制,节律控制,切除和预防心房血栓栓塞的策略.
结论:
- 深入了解AF病理生理学对于推进治疗干预至关重要.
- 未来的研究应该专注于翻译方法,以将基本机制与临床实践联系起来.
- 针对潜在的条件,重塑和子宫外源,有望改善AF管理.
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