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Updated: May 27, 2026

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脂友核酸的非共价单层穿孔固定:制备,表征和传感应用

Moria Kwiat1, Roey Elnathan, Minseok Kwak

  • 1School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

Journal of the American Chemical Society
|November 17, 2011
PubMed
概括

这项研究引入了一种新的,可逆的方法,用于使用脂质尾巴将DNA探头附在表面上. 这种技术通过允许控制的DNA固定和释放来增强生物传感器的发展,提高了DNA检测的特异性.

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Lipids as Anchors01:32

Lipids as Anchors

In the plasma membrane, the lipids forming the bilayer can also act as an anchor to tether proteins to the membrane. The three main types of lipid anchors found in eukaryotes are – prenyl groups, fatty acyl groups, and glycosylphosphatidylinositol or GPI groups. Prenyl and fatty acyl groups act as anchors on the cytosolic surface of the membrane, whereas GPI anchors proteins on the extracellular side.
The carboxy-terminal of most of the prenylated proteins, such as Ras proteins, contains the...