在昆虫中,裂纹介导了进化保守的切换到纤维肌的命运
Cornelia Schönbauer1, Jutta Distler, Nina Jährling
1Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Nature
|November 19, 2011
概括
转录因子Spalt大 (Salm) 控制了Drosophila.的纤维状飞行肌肉的发展. 这一发现揭示了昆虫肌肉类型决定的保存机制.
科学领域:
- 肌肉生理学 肌肉生理学
- 发育生物学是发展生物学.
- 遗传学 是一个遗传学.
背景情况:
- 昆虫的飞行肌肉以高频率 (高达1000Hz) 运行,并产生显著的功率.
- 纤维状飞行肌肉是拉伸激活的,从形态上不同于较慢的管状肌肉.
- 了解肌肉分化的遗传调节对于昆虫飞行机制至关重要.
研究的目的:
- 为了确定Drosophila中纤维状飞行肌肉发育的关键调节者.
- 阐明确定肌肉纤维类型的分子机制.
- 为了研究肌肉调节通路的进化保存.
主要方法:
- 在Drosophila melanogaster中进行遗传选.
- 对基因表达和拼接模式的分析.
- 昆虫物种之间的比较基因组学. 昆虫物种之间的比较基因组学.
主要成果:
- 分裂大 (Salm) 被确定为纤维状飞行肌肉命运的主调节者.
- 是诱导纤维肌肉特征的必要和足够的.
- 萨尔姆调节关键的sarcomeric组件,切换转录程序从管状到纤维状命运.
- 在被2亿8千万年分隔的昆虫中,裂功能得到了保存.
结论:
- 在发育过程中,Salm作为决定纤维肌肉身份的关键开关.
- 肌纤维分化的Spalt介导途径在昆虫中被进化保存.
- 这种保存的机制可能延伸到脊椎动物的伸展激活肌肉,如心脏.
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