用于乳腺癌查,诊断和治疗的MRI
Monica Morrow1, Janet Waters, Elizabeth Morris
1Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. morrowm@mskcc.org
Lancet (London, England)
|November 22, 2011
概括
磁共振成像 (MRI) 显示,高风险女性的乳腺癌检测灵敏度高于乳房扫描. 然而,目前的数据并不总是表明MRI查改善了存活率或治疗结果.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 磁共振成像 (MRI) 是用于高危人群乳腺癌查和治疗选择的广泛使用的工具.
- 与乳房镜相比,它在检测具有遗传突变的女性癌症方面具有更高的灵敏度.
- 然而,长期生存数据和对治疗结果的影响仍然是研究领域.
研究的目的:
- 评估MRI在乳腺癌查和治疗选择中的有效性.
- 评估MRI增加灵敏度对患者存活率和手术结果的影响.
- 审查MRI在特定临床场景中的实用性,例如新辅助化疗反应和关腺病.
主要方法:
- 对前性研究进行分析,对高风险女性癌症检测的MRI和乳房影像进行比较.
- 来自两项随机试验的数据的审查,检查MRI对手术治疗选择和结果的影响.
- 评估现有数据的长期结果,如复发和 contralateral 癌症发病率.
- 评估MRI在评估对新辅助化疗的反应和识别关腺瘤病例中的原发性瘤方面的性能.
主要成果:
- 与乳房扫描相比,MRI在具有遗传突变的女性中检测乳腺癌的灵敏度更高.
- 尽管增加了灵敏度,但MRI并没有在随机试验中始终导致改善外科治疗选择或减少手术数量.
- 关于长期结果 (复发,抵押品发生率) 的数据有限,尚未显示明确的好处.
- 磁力共振成像优于其他方法,用于评估对新辅助化疗的反应,并在患有腺瘤的患者中识别初级瘤.
结论:
- 虽然MRI在特定高风险群体中为乳腺癌检测提供了更高的灵敏度,但它对生存和手术结果的影响需要进一步的长期评估.
- 核磁共振 (MRI) 是评估治疗反应和在不明原因的腺瘤病例中的一个有价值的工具.
- 需要继续进行研究,以澄清MRI查在乳腺癌管理中的长期益处.
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