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降解性碳氧化支持瘤细胞与缺陷线粒体的生长

Andrew R Mullen1, William W Wheaton, Eunsook S Jin

  • 1Department of Pediatrics, University of Texas - Southwestern Medical Center at Dallas, Dallas, Texas 75390-9063, USA.

Nature
|November 22, 2011
PubMed
概括

有缺陷线粒体的癌细胞利用谷氨来进行还原性碳氧化,这是产生瘤生长必不可少的构建块的新途径. 当氧化代谢受损时,这种代谢适应支持宏分子合成.

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