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Updated: May 27, 2026

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods
07:49

Characterize Disease-related Mutants of RAF Family Kinases by Using a Set of Practical and Feasible Methods

Published on: July 17, 2019

RAF 抑制剂的耐药性是由异常拼接的 BRAF ((V600E) 的二元化介导的

Poulikos I Poulikakos1, Yogindra Persaud, Manickam Janakiraman

  • 1Department of Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

Nature
|November 25, 2011
PubMed
概括

在黑色素瘤中,一种对RAF抑制剂的新型耐药性机制涉及BRAF (V600E) 拼接变体. 这些变异促进了RAS-独立的二分化,导致ERK通路的活性化和患者的维穆拉费尼布耐药性.

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Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines10:16

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