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Updated: May 4, 2026

CRISPR-Mediated Reorganization of Chromatin Loop Structure
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在CRL4DDB2/CSA的分子基础上,ubiquitin合酶的架构,向和激活

Eric S Fischer1, Andrea Scrima, Kerstin Böhm

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

Cell
|November 29, 2011
PubMed
概括

CRL4 (((DDB2) 酶通过DDB2识别UV损伤的DNA,但被COP9信号体 (CSN) 抑制. 对DDB2的DNA结合释放了这种抑制,揭示了CRL4酶激活的一般机制.

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