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在心血管疾病中进行翻译研究的患者衍生细胞的表型化

Stanley Y Shaw1, Ari D Brettman

  • 1Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA. shaw.stanley@mgh.harvard.edu

Circulation
|November 30, 2011
PubMed
概括

No abstract available in PubMed .

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...