生物活性聚合体来自两性糖的聚合体
Jin Huang1, Colin Bonduelle, Julie Thévenot
1School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
Journal of the American Chemical Society
|December 14, 2011
概括
研究人员创造了新的聚类块共聚合物,并将其自组装成各种纳米结构,如聚合体. 这些聚合体体显示生物活性银河糖单位,由莱克结合证实,展示了针对性交付应用的潜力.
科学领域:
- 聚合物化学 聚合物化学
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
背景情况:
- 聚类块共聚合物为纳米医学提供了多功能平台.
- 功能性聚合物的受控合成对于先进的应用至关重要.
- 糖基化引入了特定的生物识别特性.
研究的目的:
- 合成具有不同块长度的新型聚类块共聚合物.
- 为了使这些共聚合物具有生物活性银河糖单位的功能.
- 为了研究自我组装行为,并描述由此产生的纳米结构.
主要方法:
- 序列环开放聚合N-碳素化物.
- 惠斯根循环添加"点击"反应用于糖化.
- 纳米沉方法用于自组装.
- 用于生物验证的莱克结合试验.
主要成果:
- 成功合成了具有可调节块长度的聚类块共聚合物.
- 实现了用银河糖与聚propargylglycine块的糖化.
- 控制地形成球状菌体,虫状菌体和聚合体.
- 证明了聚合体表面上银河糖单元的存在和生物活性.
结论:
- 合成的共聚合物自组装成具有控制形态的多样化纳米结构.
- 聚合体上银河糖单位的存在使得特定的生物相互作用成为可能.
- 这些糖基化聚合体对向药物输送和诊断具有前景.
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