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Updated: May 26, 2026

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity
09:45

In Vitro SUMOylation Assay to Study SUMO E3 Ligase Activity

Published on: January 29, 2018

对于Myc驱动的瘤发生,需要一个SUMOylation依赖的转录子程序

Jessica D Kessler1, Kristopher T Kahle, Tingting Sun

  • 1Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Science (New York, N.Y.)
|December 14, 2011
PubMed
概括

针对SUMO激活酶 (SAE1/2) 导致Myc驱动癌症的合成致死性. 抑制SAE1/2会破坏Mycc的功能.

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