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Updated: May 26, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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半氨酸甲基化破坏了NF-κB激活中的泛素链传感

Li Zhang1, Xiaojun Ding, Jixin Cui

  • 1Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

Nature
|December 14, 2011
PubMed
概括

肠病原性大肠杆菌NleE通过甲基化TAB2和TAB3蛋白质来阻断宿主免疫反应,这些蛋白质对NF-κB信号传递至关重要. 这种细菌效应剂使关键的无素链结合不活化,在感染期间破坏先天免疫力.

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