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在体内,GSK-3α/β激酶和粉样蛋白的产生

Tomasz Jaworski1, Ilse Dewachter, Benoit Lechat

  • 1Experimental Genetics Group, KU Leuven, Leuven, Belgium.

Nature
|December 14, 2011
PubMed
概括

这项研究研究了糖原合成酶-激酶3 (GSK-3) 在阿尔茨海默病中的作用. 研究人员没有发现证据表明GSK-3α或β直接控制大脑中的粉样蛋白前体蛋白 (APP) 处理.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...