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平衡性核酸转运体3的缺乏会扰乱溶酶体功能和巨细胞的恒常性

Chia-Lin Hsu1, Weiyu Lin, Dhaya Seshasayee

  • 1Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Science (New York, N.Y.)
|December 17, 2011
PubMed
概括

在平衡核酸转运体3 (ENT3) 中的缺陷会导致溶酶体积累和细胞清除受损,导致巨驱动的囊细胞形成. 这项研究揭示了某些溶酶体储存疾病背后的关键机制.

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