在小鼠中由化疗剂诱导的自依赖的抗癌免疫反应
Mickaël Michaud1, Isabelle Martins, Abdul Qader Sukkurwala
1INSERM, U848, Villejuif, France.
Science (New York, N.Y.)
|December 17, 2011
概括
自对于化疗来说是必不可少的,通过使腺三酸盐 (ATP) 释放来触发抗癌免疫反应. 恢复ATP水平可以提高癌症的化疗效果,使得癌症的自功能丧失.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 当它们诱导免疫细胞死亡,刺激抗癌免疫反应时,抗质化疗更有效.
- 自,一种细胞过程通常在癌症中受损,在这种免疫细胞死亡中起着关键作用.
研究的目的:
- 调查自在化疗诱导的免疫细胞死亡中的作用.
- 确定自会影响抗癌免疫反应对化疗的机制.
主要方法:
- 在自能力与自缺乏的癌症模型中比较化疗反应.
- 评估免疫细胞透 (树突细胞,T淋巴细胞) 进入瘤.
- 从垂死的瘤细胞中测量腺三酸盐 (ATP) 的释放.
- 评估抑制细胞外ATP降解酶的影响.
主要成果:
- 自对于化疗诱导的细胞死亡是不可或缺的,但对于其免疫性至关重要.
- 自能力较强的瘤在化疗后吸引了免疫细胞,这与自缺陷瘤不同.
- 抑制自抑制了死去的癌细胞中ATP的释放.
- 在自性缺陷瘤中抑制ATP降解恢复了免疫细胞招募和免疫能力强的主体中的化疗疗效果.
结论:
- 自对于化学疗法死亡细胞中ATP免疫性释放至关重要.
- 提高细胞外ATP可以增强抗瘤化疗在瘤中受损自的疗效,特别是在免疫能力强的个体中.
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