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相关概念视频

Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding01:22

Protein Folding

Overview
Peptide Bonds02:43

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

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相关实验视频

Updated: May 26, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

最终效应影响短模型形状.

Liu He1, Abel E Navarro, Zhengshuang Shi

  • 1School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China.

Journal of the American Chemical Society
|December 20, 2011
PubMed
概括

体构造研究表明,P(II) 螺旋倾向高度依赖于氨基酸序列和末端组修饰. 这一发现影响了准确的结构预测模型的开发.

科学领域:

  • 生物物理学的生物物理.
  • 化学生物学 化学生物学
  • 结构生物学 结构生物学

背景情况:

  • 之前的研究确定了阻塞的P(II) 倾向度表,表明P(II) 是主导的形状.
  • 最近对未受阻断的三的研究显示了不同的P(II) 含量,突出了潜在的上下文依赖性.

研究的目的:

  • 为了研究pH值和序列环境对P (II) 螺旋倾向的影响.
  • 为了调和来自不同模型的P(II) 倾向度量表中的差异.

主要方法:

  • 合成和光谱分析三个序列 (GXG,AcGXGNH(2),AcGGXGGNH(2) 与不同的氨基酸 (A,V,F,S).
  • 使用光谱技术进行pH依赖的形状分析.

主要成果:

  • 在GXG系列中的P(II) 含量依赖于pH值.
  • 在未被封锁的GXG系列和被封锁的AcGXGNH(2) /AcGGXGGNH(2) 系列之间观察到显著的形状差异.
  • 氨基酸P(II) 倾向对序列和充电终端组的存在敏感.

结论:

  • P(II) 倾向度表不是普遍的,并且受到序列和终端组特征的强烈影响.

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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

  • 这些发现强调了在结构预测和设计中考虑序列上下文和终端组效应的重要性.