通过化/o-金甲基化形成/电循环级联,同时合成两种环
Nilanjana Majumdar1, Keith A Korthals, William D Wulff
1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Journal of the American Chemical Society
|December 20, 2011
概括
研究人员开发了一种新的催化合成烯,在一个步骤中形成两个环. 这种高效的方法利用了菲舍尔碳化合物复合物和甲基乙烯,使得人们可以获得像拉帕醇和维生素E这样的有价值化合物.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
背景情况:
- 衍生物是重要的异环化合物,具有多样化的生物活性.
- 现有的合成路径往往需要多个步骤和恶劣的条件.
研究的目的:
- 为环系统开发一种新,高效和单步合成方法.
- 探索这种新方法对合成生物相关分子的实用性.
主要方法:
- 的α,β不和菲舍尔碳复合物的反应与功能化的propargyl.
- 级联反应包括化,o-金甲基化形成和电循环.
主要成果:
- 成功建立了一条通往染色环系统的新合成路线.
- 反应通过一连串的机制进行,在单个合成操作中生成两个环.
- 该方法用于合成拉帕切诺和维生素E.
结论:
- 这项研究介绍了第一个单步合成 chromenes,其中两个环同时形成.
- 开发的方法提供了一条有效的途径,可以获得替代的和相关的自然产品.
![Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60786.jpg&w=3840&q=50)
相关概念视频
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Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy acids to...
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