静止心率的时间变化以及因缺血性心脏病死亡的情况
Javaid Nauman1, Imre Janszky, Lars J Vatten
1K. G. Jebsen Center of Exercise in Medicine, PO Box 8905, Medisinsk Teknisk Forskningssenter, 7491 Trondheim, Norway.
JAMA
|December 22, 2011
概括
十年来,静止心率 (RHR) 的增加与因缺血性心脏病 (IHD) 死亡的风险更高有关. 这项研究强调了监测RHR变化对心血管健康的重要性.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 休息心率 (RHR) 是已知的心血管风险预测指标.
- 时间RHR变化对一般人群缺血性心脏病 (IHD) 死亡率的影响尚不清楚.
研究的目的:
- 调查RHR长期纵向变化与IBH死亡风险之间的关联.
- 评估RHR波动与全因死亡率之间的关系.
主要方法:
- 在挪威对29325个人进行前性队列研究,其中RHR测量了两次,大约10年间隔.
- 使用考克斯回归分析,根据RHR变化估计IHD和全因死亡率的危险比率.
- 死亡率的随访一直持续到2008年12月31日.
主要成果:
- 在10年的时间里,RHR的增加与IBH死亡风险显著增加有关.
- 参与者的RHR从<70增加到>85次/分钟,他们的IHD死亡风险增加了1.9倍.
- RHR变化与IHD死亡率之间的关联不是线性的,没有观察到降低RHR对死亡率的好处.
结论:
- 在没有先前心血管疾病的个体中,十年来RHR的上升与IHD死亡率的风险增加有关.
- 随着时间的推移,增加的RHR也与增加的全因死亡率相关,尽管比IHD死亡率更小.
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