印制和非印制聚合物的结合特性之间的联系:分子印制的视角变化
Claudio Baggiani1, Cristina Giovannoli, Laura Anfossi
1Laboratory of Bioanalytical Chemistry, Department of Analytical Chemistry, University of Torino, Torino, Italy. claudio.baggiani@unito.it
Journal of the American Chemical Society
|December 23, 2011
概括
分子印记依赖于模板分子,增强先前存在的聚合物结合特性. 具有固有的结合能力的非印制聚合物 (NIP) 产生了显著改进的印制聚合物 (MIP).
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 分析化学 分析化学
背景情况:
- 传统的分子印记假设结合点仅在模板周围的聚合过程中产生.
- 在这个范式中,非印制聚合物 (NIP) 的固有结合特性在很大程度上被忽视了.
- 这忽略了先前存在的聚合物特性对印记效率的潜在贡献.
研究的目的:
- 提出和验证分子印记的另一种观点,其中模板增强了先前存在的聚合物结合.
- 调查NIP结合性质与印制聚合物 (MIP) 的后续性能之间的相关性.
- 为了确定绑定选择性是否是印记过程的新兴属性.
主要方法:
- 准备一个没有模板分子的96个成员的组合聚合物库 (NIP库).
- 对NIP库进行选,以确定它对各种点分子的结合亲和力.
- 合成相应的印制聚合物 (MIP),使用性能最好的NIP配方,并验证纳普和布洛芬的结合特性.
主要成果:
- 观察到NIP的约束性和相应的MIP之间存在很强的相关性.
- 具有较高固有的结合亲和度的NIP配方产生了具有显著增强结合能力的MIP.
- 对于密切相关的分子的结合选择性被证明是印记过程中出现的特性,在NIP中不存在.
结论:
- 印记效应受到高分子矩阵先前存在的结合性质的显著影响.
- 选择具有固有的结合亲和性适当的聚合物前体对于开发高效印制聚合物至关重要.
- 分子印记增强,而不是仅仅创造,结合点,选择性来自印记过程本身.
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