维夫劫持CBF-β降低APOBEC3G和促进HIV-1感染

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Isolation of Viral Replication Compartment-enriched Sub-nuclear Fractions from Adenovirus-infected Normal Human Cells
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Published on: November 12, 2015

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Stefanie Jäger1, Dong Young Kim, Judd F Hultquist

  • 1Department of Cellular and Molecular Pharmacology, University of California-San Francisco, San Francisco, California 94158, USA.

Nature
|December 23, 2011
PubMed
概括

人类免疫缺陷病毒1型 (HIV-1) Vif蛋白质劫持细胞机械,降解APOBEC3G,这是一个关键的抗病毒因素. 这项研究揭示了转录辅因子CBF-β对于这一过程至关重要,提供了潜在的治疗点.

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