相关实验视频
Updated: May 26, 2026
09:37
In vivo Optogenetic Stimulation of the Rodent Central Nervous System
Published on: January 15, 2015
微生物子家族的光遗传工具
Feng Zhang1, Johannes Vierock, Ofer Yizhar
1Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. zhang_f@mit.edu
Cell
|December 27, 2011
概括
微生物素是紧的,快速光激活的蛋白质. 分子工程和基因组学的进步正在增强它们在光遗传学中的使用,并了解这些分子机器.
科学领域:
- 生物物理学的生物物理.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 光的捕获和利用是基本的生物过程.
- 与复杂的系统相比,单元微生物素提供了独特的速度和紧性.
- 光遗传学和比较基因组学推动了近期在光研究中的进展.
研究的目的:
- 提供对微生物素的基础知识,重点关注光激活的离子通道和.
- 描述一种新的opsins群体,可以弥合现有的功能类别.
- 为了探索分子工程和基因组发现之间的协同作用,用于opsin应用.
主要方法:
- 文献综述和对当前有关微生物的研究进行综合研究.
- 对最近的光遗传学分子工程策略的分析.
- 进行比较的基因组方法来识别和分类opssin家族.
主要成果:
- 微生物素结构功能关系的详细概述.
- 识别具有独特属性和潜在应用的opssin子类.
- 演示如何结合工程和基因组洞察力推进选择的理解.
结论:
- 微生物素是多功能分子机器,在生物技术和基础科学方面具有重大潜力.
- 分子工程和基因组发现的整合加速了opsins的开发和应用.
- 进一步的研究有望更深入地了解opsin进化和新型功能应用.
相关概念视频
01:11Channel Rhodopsins
Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
02:09Operons
Prokaryotes can control gene expression through operons—DNA sequences consisting of regulatory elements and clustered, functionally related protein-coding genes. Operons use a single promoter sequence to initiate transcription of a gene cluster (i.e., a group of structural genes) into a single mRNA molecule. The terminator sequence ends transcription. An operator sequence, located between the promoter and structural genes, prohibits the operon’s transcriptional activity if bound by a repressor...