减肥手术和长期心血管事件
Lars Sjöström1, Markku Peltonen, Peter Jacobson
1Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. lars.v.sjostrom@medfak.gu.se
JAMA
|January 5, 2012
概括
与常规护理相比,减肥手术显著减少了肥胖成年人的心血管死亡和事件. 这种减肥干预措施提供了防止主要心血管结果的保护.
科学领域:
- 心血管健康 心血管健康
- 肥胖医学 肥胖医学
- 手术创新 在外科创新.
背景情况:
- 肥胖是心血管事件的重要危险因素.
- 支持减肥干预措施为心血管保护的证据有限.
- 减肥手术是严重肥胖症的主要减肥干预措施.
研究的目的:
- 调查减肥手术与心血管事件之间的关联.
- 评估手术减肥对心血管死亡率和发病率的影响.
- 为肥胖个体提供减肥手术对心血管的益处提供证据.
主要方法:
- 瑞典肥胖受试者 (SOS) 研究是一项前性,受控,非随机试验.
- 2010年,肥胖的参与者接受了减肥手术;2037名匹配的肥胖对照接受了通常的护理.
- 随访时间平均为14.7年,分析了心血管死亡,心肌梗塞和中风.
主要成果:
- 腹腔外科手术与较少的心血管死亡有关 (HR,0.47;P = .002).
- 整体心血管事件 (心肌梗塞或中风) 的发生率在手术组较低 (HR,0.67;P < .001).
- 经过调整以考虑混因素后,这些发现仍然很重要.
结论:
- 减肥手术与肥胖成年人心血管死亡人数减少有关.
- 与接受常规护理的人相比,接受减肥手术的肥胖个体患心血管事件的发生率较低.
- 这项研究提供了强有力的证据,证明了减肥手术对心血管的保护作用.
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