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Generation of Null Mutants to Elucidate the Role of Bacterial Glycosyltransferases in Bacterial Motility
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双糖的功能需要LARGE的西洛西尔和葡萄糖转移酶活动

Kei-ichiro Inamori1, Takako Yoshida-Moriguchi, Yuji Hara

  • 1Howard Hughes Medical Institute, Department of Molecular Physiology and Biophysics, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 4283 Carver Biomedical Research Building, 285 Newton Road, Iowa City, IA 52242-1101, USA.

Science (New York, N.Y.)
|January 7, 2012
PubMed
概括

类似乙糖氨基基转移酶 (LARGE) 酶修改了α-dystroglycan (α-DG),使其能够结合细胞外矩阵连接物. 这种双功能酶对适当的α-DG功能至关重要,可能是治疗肌肉衰竭的关键.

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