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朗格汉斯细胞促进上皮细胞DNA损伤和状细胞癌

Badri G Modi1, Jason Neustadter, Elisa Binda

  • 1Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA.

Science (New York, N.Y.)
|January 7, 2012
PubMed
概括

朗格汉斯细胞 (LCs) 代谢致癌的多芳香碳化合物 (PAHs),如DMBA,促进皮肤癌. 移除LCs保护小鼠免受PAH诱导的DNA损伤和突变,揭示了这些免疫细胞在化学致癌过程中的关键作用.

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