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相关概念视频

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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相关实验视频

Updated: May 26, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

合成聚合物纳米粒子-多糖相互作用:一个系统的研究研究.

Zhiyang Zeng1, Jiten Patel, Shih-Hui Lee

  • 1Department of Chemistry, University of California, Irvine, Irvine, California 92697, USA.

Journal of the American Chemical Society
|January 11, 2012
PubMed
概括

合成聚合物纳米粒子与诸如肝素之类的多糖体相互作用,影响它们的生物命运. 了解这些相互作用指导了纳米粒子用于生物医学应用的工程,包括治疗用途.

科学领域:

  • 生物材料科学 生物材料科学
  • 纳米技术 纳米技术
  • 聚合物化学 聚合物化学

背景情况:

  • 生物大分子,包括多糖,对于细胞功能和组织结构至关重要.
  • 合成聚合物纳米粒子 (NP) 与生物大分子相互作用,影响它们在生物系统中的行为.
  • 肝素及其衍生物是参与许多生物过程的关键多糖.

研究的目的:

  • 系统地研究合成聚合物纳米粒子和多糖之间的相互作用.
  • 为基于NP-多糖相互作用的生物医学应用工程纳米颗粒提供指导方针.
  • 探索合成聚合物纳米颗粒在调节蛋白质-氨酸相互作用中的潜在治疗应用.

主要方法:

  • 异热定位热量计 (ITC) 用于确定结合亲和力和热力学.
  • 表面等离子共振 (SPR) 分析实时结合动力学.
  • 抗凝剂测试用于评估NP-赫巴林相互作用的功能后果.

主要成果:

  • 烯胺纳米颗粒 (~30nm) 显示出对肝素的亚微分子亲和力,主要由力驱动.
  • 关键的相互作用包括结,离子相互作用和极性群体的脱水.
  • 高的NP电荷密度和交叉链接增强了亲和力;盐度显著降低了亲和力,而温度的影响很小.

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Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
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Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

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Last Updated: May 26, 2026

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles

Published on: July 6, 2012

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
09:02

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization

Published on: July 9, 2015

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

  • 将NP聚合物从烯胺转换为N-异烯胺,将结合热力学从受驱动转变为受驱动,改变对盐和温度的反应.
  • 一些合成聚合物纳米颗粒抑制了蛋白质和氨酸的相互作用.

    • 结论:

    • 合成聚合物纳米粒子和多糖之间的相互作用是复杂的和可调节的.
    • 了解结合热力学和影响亲和力的因素对于设计有效的纳米药物至关重要.
    • 合成聚合物纳米粒子通过调节关键的生物宏分子相互作用,显示出治疗应用的前景.