超过20年的大麻暴露与肺功能之间的关联
Mark J Pletcher1, Eric Vittinghoff, Ravi Kalhan
1Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry St, Ste 5700, San Francisco, CA 94107, USA. mpletcher@epi.ucsf.edu
JAMA
|January 12, 2012
概括
偶尔使用大麻不会损害肺功能,但大量使用显示出混合的结果. 这项研究分析了大麻.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 大麻烟雾与烟草烟雾具有相同的成分,这引发了对其对肺功能影响的质疑.
- 关于大麻对肺部影响的现有研究是有限的,有时是相互矛盾的.
- 了解剂量反应关系对于公共卫生指导至关重要.
研究的目的:
- 调查大麻暴露 (当前和终身) 与肺功能之间的关联.
- 为了比较大麻与烟草烟雾对肺部容量的影响.
- 为了确定大麻的使用是否对呼吸系统健康有线性或非线性影响.
主要方法:
- 利用了从年轻成年人 (CARDIA) 纵向冠状动脉风险发展研究 (20年) 的数据.
- 在5115名参与者中分析了肺功能指标 (FEV(1),FVC).
- 采用混合线性建模,将烟草使用作为对照,并在联合年中量化大麻暴露.
主要成果:
- 烟草使用与FEV降低线性相关{}1) 和FVC.
- 大麻与肺功能的关联是非线性的.
- 低水平的大麻使用显示FEV和FVC略有增加;大量使用显示这些效应平衡或逆转,而FVC仍然升高.
结论:
- 偶尔和低度的累积大麻使用与不良的肺功能无关.
- 强度大麻使用对肺功能表现出复杂,非线性影响.
- 需要进一步的研究才能充分阐明大量大麻消费对肺部的长期后果.
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