在子宫内和新生儿侮辱后的长期神经发育结果:系统性审查
Michael K Mwaniki1, Maurine Atieno, Joy E Lawn
1Centre for Geographic Medicine Research (Coast), Kenya Medical Research Institute, Kilifi, Kenya. michael.kivkiv@gmail.com
Lancet (London, England)
|January 17, 2012
概括
新生儿侮辱导致幸存者的长期神经认知和发育问题. 在低收入国家进行进一步的研究对于了解和解决这一全球健康负担至关重要.
科学领域:
- 全球卫生健康 全球卫生健康
- 新生儿护理 新生儿护理
- 神经发育障碍 神经发育障碍
背景情况:
- 新生儿干预主要侧重于降低死亡率,对长期后果的理解有限.
- 宫内和新生儿的侮辱构成了长期健康问题的重大,但尚未研究的风险.
- 特别需要在低收入和中等收入国家评估这些风险.
研究的目的:
- 系统地审查和估计子宫内和新生儿侮辱后长期神经认知和其他后果的风险.
- 在资源有限的环境中专门评估这些风险.
主要方法:
- 进行了一项系统性审查,搜索多个数据库 (Medline,CINAHL,Cochrane Library,Embase) 从1966年到2011年的研究.
- 包括的研究报告了早产或新生儿侮辱后的神经发育后续,重点关注长期结果.
- 用中位数和IQR总结了数据,并计算了至少一个后续的风险.
主要成果:
- 包括153项记录了22,161名幸存者的研究.
- 总体中位数风险至少一个序列是39.4%,严重损伤的风险为18.5%.
- 常见的后果包括学习困难/发育迟缓 (59%),脑 (21%),听力障碍 (20%) 和视力障碍 (18%).
结论:
- 宫内和新生儿的侮辱带有长期的神经疾病的高风险.
- 需要对资源贫困地区进行可比的队列研究,以准确评估这些条件的负担.
- 调查结果强调需要政策和计划投资来解决长期结果.
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