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Non-invasive Assessment of Microvascular and Endothelial Function
Published on: January 29, 2013
性别在皮肤血流控制方面的差异
J P Cooke1, M A Creager, P J Osmundson
1Division of Vascular Medicine, Brigham and Women's Hospital, Boston.
Circulation
|November 1, 1990
概括
女性患雷诺氏病的比例较高,原因是同情神经系统控制皮肤血流的差异. 这项研究发现,女性的基底血流量较低,这表明同情性外流增加,这会影响她们对刺激的反应.
科学领域:
- 生理学 生理学 生理学
- 血管生物学 血管生物学
- 神经科学是一个神经科学.
背景情况:
- 雷诺氏病不成比例地影响女性.
- 了解皮肤血流调节中的基于性别的差异对于解释这种差异至关重要.
研究的目的:
- 调查皮肤血流的中央和地方控制中的性别差异.
- 确定这些差异是否有助于女性雷诺病的发病率更高.
主要方法:
- 在47名志愿者中测量了手部血流 (HBF),手指血流 (FBF) 和皮肤 perfusion (SP),使用流体囊造影,压力计囊造影和激光多普勒光谱.
- 评估血流对热刺激 (升温和降温),精神压力和深度灵感的反应.
主要成果:
- 与女性相比,男性表现出更高的基底HBF,FBF和SP.
- 总体变暖增加了女性的HBF比男性更多,这表明女性的基础交感外流更高.
- 心理压力和深刻的灵感减少了男性的血液流动,但矛盾的是,增加了女性的血液流动.
- 冷却的男人增加了同情的基调,并扭转了他们对压力的反应,而温暖的女人减少了同情的基调.
结论:
- 女性具有较低的基底皮肤血流,可能是由于交感神经系统活动增加.
- 皮肤血管的交感控制中的性别特异可能是雷诺氏病在女性中更高的患病率的基础.
- 这些发现突出了神经血管调节在循环状况的性别差异中的作用.
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