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神经元类型特定的奖励和惩罚信号在腹部体区域
Jeremiah Y Cohen1, Sebastian Haesler, Linh Vong
1Department of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA.
Nature
|January 20, 2012
概括
腹部体区域 (VTA) 的GABA活性神经元发出预期的奖励信号. 这一发现对于理解多巴胺基神经元如何计算奖励预测错误信号至关重要,这对于激励和奖励处理至关重要.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 奖励系统奖励系统
背景情况:
- 多巴胺在激励和奖励中起着至关重要的作用.
- 众所周知,腹部体区域 (VTA) 的多巴氨基神经元会发出奖励预测错误的信号.
- 在VTA中这些信号的精确计算机制在很大程度上是未知的.
研究的目的:
- 调查VTA中奖励预测错误计算背后的神经机制.
- 区分与预期与实际奖励相关的神经元活动模式.
- 确定负责信号预期奖励值的特定神经元群体.
主要方法:
- 在小鼠的体内电生理学记录.
- 关联式学习任务涉及气味线索和食欲/厌恶结果.
- 使用通道罗多普辛-2的多巴aminergic和GABAergic神经元的光遗传标记.
- 对线索,结果和光学刺激的神经元反应的分析.
主要成果:
- 在VTA中发现了三种不同的神经反应类型 (I,II,III).
- 一类神经元 (52%) 呈现奖励预测错误的编码,对实际的奖励做出反应.
- 第二类 (31%) 和第三类 (18%) 神经元表现出由预期奖励值调节的持续活动,第二类是GABAergic,第一类是dopaminergic.
结论:
- VTA GABAergic神经元 (II型) 信号预期的奖励值.
- VTA多巴胺基神经元 (I型) 处理奖励预测错误,利用预期值信息.
- 这项研究阐明了VTAGABAergic和dopaminergic神经元在奖励处理和学习中的独特作用.
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