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相关概念视频

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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相关实验视频

Updated: May 10, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

连接线索:表观遗传学和新陈代谢

Sayako Katada1, Axel Imhof, Paolo Sassone-Corsi

  • 1Center for Epigenetics and Metabolism, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.

Cell
|January 24, 2012
PubMed
概括

饮食影响后代的表观遗传学,这表明基因组能感知新陈代谢. 了解代谢物水平如何控制染色体修饰剂是将代谢状态转化为稳定的基因表达模式的关键.

科学领域:

  • 表观遗传学和分子生物学
  • 代谢调节 代谢调节 代谢调节
  • 控制基因表达 控制基因表达

背景情况:

  • 建议使用染色体修饰酶来调解表观遗传.
  • 饮食影响可以通过表观遗传传给后代.
  • 基因组可以作为代谢传感器,将代谢与基因表达联系起来.

研究的目的:

  • 研究染色质修饰酶在表观遗传中的作用.
  • 探索质子如何作为代谢传感器.
  • 了解代谢物波动影响色素修饰的机制.

主要方法:

  • 调查饮食和表观遗传修饰之间的联系.
  • 分析作为代谢状态指标的基因组修饰.
  • 通过代谢产物研究染色质修饰剂的空间和时间控制.

主要成果:

  • 有证据表明,饮食诱导的表观遗传变化是可以遗传的.
  • 基因组似乎将代谢信号转化为基因表达模式.
  • 代谢物波动动动态调节色氨酸修饰剂.

结论:

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Unveiling Histone Proteoforms using 2D-TAU Gel Electrophoresis
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  • 染色体修饰剂在表观遗传中起着至关重要的作用.
  • 基因组体作为代谢状态和基因表达之间的桥梁.
  • 需要进一步的研究来阐明代谢物驱动的染色质调节的精确机制.