衰老,再生和表观遗传重编程:重置衰老时钟
Thomas A Rando1, Howard Y Chang
1The Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA. rando@stanford.edu
Cell
|January 24, 2012
概括
衰老是一个生物学上的,但新的研究表明,衰老的时钟可以逆转. 表观遗传重编程提供了一个框架,以理解和潜在地恢复年轻的衰老的细胞和组织.
科学领域:
- 生物学 生物学 生物学
- 遗传学 是一个遗传学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 驱动衰老过程的基本机制在很大程度上是未知的.
- 最近的研究表明,衰老是可塑的,可能是可逆的.
研究的目的:
- 在生物衰老的背景下,审查表观遗传重编程的新兴领域.
- 探索如何将年轻和衰老定义为表观遗传状态可以促进衰老研究.
主要方法:
- 关于衰老和复苏的最新研究的文献综述.
- 专注于表观遗传重编程作为一个关键机制.
主要成果:
- 有证据表明,衰老的速度可能受到遗传和环境因素的影响.
- 衰老过程可能是可逆的,有可能恢复年轻的特征.
结论:
- 表观遗传重编程为研究衰老提供了一个新的框架.
- 将青春和衰老视为表观遗传状态,为研究衰老逆转开辟了新的途径.
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