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Updated: Jan 27, 2026

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需要对NBD1能量和域接口进行校正,以恢复 ΔF508 CFTR 折叠和功能

Wael M Rabeh1, Florian Bossard, Haijin Xu

  • 1Department of Physiology, McGill University, Montréal, Quebec H3E 1Y6, Canada.

Cell
|January 24, 2012
PubMed
概括

纠正囊性纤维化跨膜导电调节器 (CFTR) 错误折叠需要稳定NBD1域能量和NBD1-MSD2接口. 这种双重方法对于恢复CFTR蛋白的功能和运输至关重要.

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