协调的状拍打需要通过基底脚通过基底体的ODF2介导的两极分化
Koshi Kunimoto1, Yuji Yamazaki, Tomoki Nishida
1Laboratory of Biological Science, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
Cell
|January 24, 2012
概括
Odf2蛋白对于在乳毛上形成基脚是必不可少的. 基本脚的损失会扰乱协调的状脉动,影响气道清除,并导致小鼠的呼吸症状.
科学领域:
- 细胞生物学 细胞生物学
- 呼吸系统生物学 呼吸系统生物学
- 分子生物学分子生物学
背景情况:
- 气管中的乳头座标为粘液清除的跳动.
- 乳毛起源于基底体,这些基底体与基底脚有关.
- Odf2/cenexin是一种与基底体和中心体相关的蛋白质.
研究的目的:
- 研究Odf2在基底体形成和功能中的作用.
- 为了确定基底脚在纤毛协调和气道清除中的重要性.
主要方法:
- 生成的Odf2(ΔEx6,7/ΔEx6,7) 的小鼠具有破坏的Odf2外显子6和7.
- 分析了突变小鼠的状结构,跳动协调和呼吸道表型.
- 检查了尖端微管网的极化组织.
主要成果:
- Odf2(ΔEx6,7/ΔEx6,7) 的小鼠形成了眼,但表现出不协调的跳动和呼吸问题.
- 剩余的Odf2表达支持纤毛发育,但导致基底体缺乏基底脚.
- 基本脚的损失破坏了角微管网组织,但没有影响平面细胞极性.
结论:
- Odf2对于足底形成至关重要.
- 基底脚对于基底体的极化对齐至关重要.
- 需要正确的基底身体对齐,以协调状拍打和有效的气道清除.
相关概念视频
Mechanism of Ciliary Motion
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Ciliary Motion
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Mechanism of Filopodia Formation
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Microtubules in Cell Motility
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Microtubules in Cell Motility
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
Forces Acting on Chromosomes
During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis.
Microtubules and motor proteins exert two types of forces on...
Microtubules and motor proteins exert two types of forces on...


