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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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在以19F-NMR为特征的β2-上腺素受体中存在偏差信号通路

Jeffrey J Liu1, Reto Horst, Vsevolod Katritch

  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|January 24, 2012
PubMed
概括

与G蛋白结合受体 (GPCRs) 结合的连接体会改变受体结构. 激动剂通过螺旋 VI 激活 G 蛋白信号传递,而偏向的连接体则影响螺旋 VII,影响β 停滞信号传递.

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