相关实验视频
Updated: May 25, 2026

14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
概括
质子抑制剂兰索普拉在控制不良的喘和没有明显的GER症状的儿童中没有改善喘控制. 药物没有改善喘症状或肺功能,并增加了呼吸道感染.
科学领域:
- 儿科肺病学 儿科肺病学
- 胃肠病学 胃肠病学
背景情况:
- 无症状的胃食道逆流 (GER) 在患有喘的儿童中很常见,可能导致喘控制不良.
- 质子抑制剂 (PPI) 对改善没有明显GER症状的儿童喘控制的疗效尚未得到充分证实.
研究的目的:
- 评估兰索普拉在改善控制不良但没有明显GER症状的喘儿童中改善喘控制的有效性.
主要方法:
- 一项随机化,蒙面,安慰剂控制的试验 (喘儿童的酸反流研究) 涉及306名吸入性皮质类固醇治疗控制不良喘儿童.
- 参与者接受了兰索普拉或安慰剂24周.
- 喘控制问卷 (ACQ) 评分是主要结果;肺功能和生活质量是次要结果.
主要成果:
- 与安慰剂相比,兰索普拉没有显著改善ACQ得分 (平均差异为0.2单位).
- 没有观察到肺功能,喘相关的生活质量或喘控制不良的情节有显著差异.
- 胃食道逆流 (GER) 存在于食道pH研究的子组中的43%,但兰索普拉在这个子组中没有益处.
- 接受兰索普拉的儿童报告了更多的呼吸道感染 (RR,1.3).
结论:
- 兰索普拉在改善喘症状或肺功能方面并不有效,在儿童中,喘控制不良,没有明显的GER症状.
- 在这一群体中,兰索普拉的使用与呼吸道感染的风险增加有关.
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