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Updated: Jan 15, 2026

In Vivo CRISPR/Cas9 Screening to Simultaneously Evaluate Gene Function in Mouse Skin and Oral Cavity
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G-蛋白结合受体被一个全osteric逆agonist抗体的失活

Tomoya Hino1, Takatoshi Arakawa, Hiroko Iwanari

  • 1Iwata Human Receptor Crystallography Project, ERATO, Japan Science and Technology Agency, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Nature
|January 31, 2012
PubMed
概括

研究人员开发了一种新型抗体,该抗体与A2A腺受体 (A2A) 结合,将其锁定在非活性状态中. 这一发现为调节G蛋白结合受体活性提供了一种新方法.

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