对脂酶敏感的聚合物三层纳米凝用于"按需"药物输送
Meng-Hua Xiong1, Yan Bao, Xian-Zhu Yang
1CAS Key Laboratory of Soft Matter Chemistry and Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.
Journal of the American Chemical Society
|February 7, 2012
概括
研究人员开发了一种新型的脂酶敏感纳米凝,用于有针对性的抗微生物药物输送. 这种智能药物载体将抗生素释放到细菌感染部位,从而提高各种感染的治疗效率.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 传染性疾病 传染性疾病
背景情况:
- 针对性的抗微生物药物供应仍然是治疗细菌感染的挑战.
- 传统的抗生素往往缺乏特异性,导致非目标效应和有效性降低.
- 开发智能药物输送系统对于改善治疗结果至关重要.
研究的目的:
- 开发一种新型的脂酶敏感聚合物三层纳米凝 (TLN) 用于向的抗菌药物输送.
- 为了研究抗生素在对细菌存在的反应中得到控制的释放.
- 评估TLN在治疗细胞外和细胞内细菌感染方面的疗效.
主要方法:
- 使用手臂第一程序合成TLN,使用单甲基聚 ((乙烯糖醇) -b-聚 ((ε-caprolactone) 和双功能单体.
- 在存在或缺乏脂酶分泌细菌 (黄金葡萄球菌) 的情况下,TLN的药物释放性质的表征.
- 在体外评估万科米辛的释放和抗菌活性对黄金色杆菌.
- 评估TLN向受感染细胞输送药物和消除细胞内细菌的能力.
主要成果:
- 合成的TLN有效地防止了抗生素过早释放.
- TLN表现出对脂酶敏感的降解,在24小时内释放封装的万科米辛,特别是在S. aureus.的存在下.
- 观察到显著抑制金黄色细菌的生长.
- TLN成功地将药物输送到受感染的细胞中,从而有效地杀死细胞内细菌.
结论:
- 开发的脂酶敏感TLN为针对性抗微生物药物输送提供了新的战略.
- 这种方法提供了一种安全,有效和通用的方法,用于治疗由脂酶分泌细菌引起的细胞外和细胞内细菌感染.
- 对于推进抗微生物疗法,TLN系统具有前景.
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