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Updated: May 25, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
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在核中,PKCε促进ATF2的致癌功能,同时阻断其在线粒体中的亡功能

Eric Lau1, Harriet Kluger, Tal Varsano

  • 1Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

Cell
|February 7, 2012
PubMed
概括

转录因子ATF2通过局部化到线粒体,在皮肤癌中起到瘤抑制作用. 然而,黑色素瘤中高水平的PKCε阻断了这种功能,促进了癌症的进展.

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