模块化遗传控制性二态性行为
Xiaohong Xu1, Jennifer K Coats, Cindy F Yang
1Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA.
Cell
|February 7, 2012
概括
性激素调节大脑中的特定基因,控制不同的性别特异性行为,如侵略和交配. 破坏这些基因会导致小鼠有针对性的行为缺陷.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 行为遗传学 行为遗传学
背景情况:
- 性激素 (雌激素,) 对于性二态行为至关重要.
- 对于这些行为,将激素与神经回路连接起来的分子机制尚不清楚.
研究的目的:
- 在大脑中识别激素调节基因.
- 确定这些基因在性别特异性行为中的作用.
主要方法:
- 分析了成年小鼠下丘脑和杏仁体中的基因表达模式.
- 研究了向基因干扰对行为的影响.
主要成果:
- 确定了许多由性激素调节的两形性基因表达模式.
- 破坏四个特定的基因 (Brs3,Cckar,Irs4,Sytl4) 导致男性性行为,侵略性,母性行为或女性性行为的精确缺陷.
结论:
- 性激素控制着独特的遗传程序,这些遗传程序是性二态行为的特定组成部分的基础.
- 这些发现揭示了复杂行为的可分离的遗传基础.
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