树突细胞在心脏病发作后愈合和左心室重塑中的调节作用
Atsushi Anzai1, Toshihisa Anzai, Shigenori Nagai
1Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan. anzai@cpnet.med.keio.ac.jp
Circulation
|February 7, 2012
概括
树突细胞 (DCs) 对于心肌梗塞后的心脏愈合至关重要. 消去DCs通过促进炎症和改变免疫细胞平衡,恶化了心脏功能.
科学领域:
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 再生医学是一种再生医学.
背景情况:
- 炎症和免疫反应对于心肌梗塞后的愈合至关重要.
- 之前已经观察到心脏梗塞中树突细胞 (DC) 透,但它们的确切作用尚不清楚.
研究的目的:
- 为了研究树突细胞 (DCs) 在心肌梗塞后的愈合过程中的特定贡献.
- 阐明DCs在心脏病发作后心脏微环境中的免疫调节作用.
主要方法:
- 从转基因小鼠获得的骨髓衍生细胞移植到接受者小鼠中.
- 在接受心肌梗塞的小鼠中,使用喉毒素去除了状细胞 (DCs).
- 分析了左心室功能,心脏重塑,细胞因子表达,细胞外矩阵降解和免疫细胞透.
主要成果:
- 电流切除导致左心室功能恶化和心肌梗塞后心肌梗塞重塑.
- 经DC剥离的心脏表现出炎症性细胞因子 (IL-1β,IL-18,TNF-α) 和矩阵金属蛋白酶-9活性增加.
- 电流除导致单细胞/巨细胞群的变化,有利于亲炎性M1而不是抗炎性M2表型.
结论:
- 树突细胞 (DCs) 在心肌梗塞后的愈合中充当强大的免疫保护性调节剂.
- DCs控制单细胞和巨细胞的平静,从而影响心脏的修复和功能.
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