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在光敏感表面活性剂溶液中的细胞大小的多元脂质囊泡的紫外线诱发的破裂

Antoine Diguet1, Miho Yanagisawa, Yan-Jun Liu

  • 1Department of Chemistry, Ecole Normale Supérieure, 24 rue Lhomond, 75005 Paris, France.

Journal of the American Chemical Society
|February 10, 2012
PubMed
概括

紫外线照射会爆发含有光敏感性AzoTAB表面活性剂的巨型单囊 (GUVs). 破裂速率取决于AzoTAB和胆固醇水平,使药物输送能够选择性地破坏GUV.

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Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...