塞福多克西姆与西普罗夫洛克萨用于急性无并发性囊炎的短期治疗:一项随机试验
Thomas M Hooton1, Pacita L Roberts, Ann E Stapleton
1Department of Medicine, School of Medicine, University of Miami, Miami, Florida 33136, USA. thooton@med.miami.edu
JAMA
|February 10, 2012
概括
在治疗急性无并发性囊炎方面,Cefpodoxime并没有被发现与西普罗夫洛克萨辛无劣. 这项研究表明,Cefpodoxime不是诺基诺的首线替代品.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 诺基诺是尿路感染的标准药物,但抗性增加需要替代药物.
- 有效的诺基诺节约剂对于管理不复杂的囊炎至关重要.
研究的目的:
- 为了评估 cefpodoxime 是否在急性囊炎治疗中是西普罗夫洛克萨的非劣质替代品.
- 为了比较临床和微生物学治愈率,并评估阴道大肠杆菌殖民.
主要方法:
- 一个随机,双盲试验,涉及300名急性无并发性囊炎的妇女.
- 对比3天的西普罗夫洛克萨治疗方案与Cefpodoxime proxetil.
- 治疗后5-9天和28-30天评估结果,包括临床治愈和大肠杆菌殖民.
主要成果:
- 与 cefpodoxime 相比,西普洛克萨的临床治愈率 (93%与82%的治疗意图相比) 和微生物治愈率 (96%与81%相比) 更高.
- 塞夫多克西姆与西普罗夫洛克萨辛相比没有满足非劣质性标准.
- 阴道大肠杆菌的殖民性在塞福多西姆组显著高 (40%对16%).
结论:
- 塞夫多克西姆在急性无并发性囊炎中没有显示出与西普罗夫洛克萨辛的非劣质性.
- 对于广谱剂的生态影响的担忧,不支持将 cefpodoxime 作为一线诺基诺节约选择.
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