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Updated: May 25, 2026

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序列选择性单分子基化与pyrrole-imidazole聚胺可视化在DNA纳米支架中

Tomofumi Yoshidome1, Masayuki Endo, Gengo Kashiwazaki

  • 1Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.

Journal of the American Chemical Society
|February 11, 2012
PubMed
概括

我们开发了一种新的方法,可以使用合成聚胺在DNA原木脚手架上可视化DNA化. 这种技术精确地准和标记特定的DNA序列,甚至可以区分单基不匹配.

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Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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