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High-throughput Screening for Protein-based Inheritance in S. cerevisiae
Published on: August 8, 2017
子是野生酵母体表型遗传的一个常见机制
Randal Halfmann1, Daniel F Jarosz, Sandra K Jones
1Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.
Nature
|February 17, 2012
概括
酵母或自我模拟蛋白在野生菌株中很常见,并赋予各种有益的特征. 这些表观遗传元素可以推动自然种群的适应和进化.
科学领域:
- * 分子生物学 * 分子生物学
- * 遗传学 遗传学是一门学科
- * 进化生物学 进化生物学
背景情况:
- *酵母子是自我模拟的蛋白质,可以作为表观遗传元素,可能驱动遗传的表型多样性和适应性.
- * 子在自然种群中的作用及其对进化的贡献是有争议的,有些人将它们视为罕见的实验室文物.
研究的目的:
- * 调查在野生Saccharomyces菌株中酵母子 ([PSI(+) 和[MOT3(+) ]的流行率和功能意义.
- * 确定这些子在选择性条件下是否赋予有益的表型,并有助于适应性进化.
主要方法:
- *对大约700种野生Saccharomyces菌株进行生物化学测试,以检测[PSI(+) ]或[MOT3(+) ]的存在.
- * 基因查,以确定野生菌株中未知的元素.
- *在选择性条件下对子载体菌株进行表型分析.
主要成果:
- * [PSI(+) ]和[MOT3(+) ]子在许多野生Saccharomyces菌株中被发现,而不仅仅是实验室菌株.
- * 这些子赋予了多样化且经常有益的表型,有助于在选择性压力下生存.
- *三分之一的野生菌株含有未知的元素,也产生了多样化,往往有利的表型.
- *有益的特征可以通过介质重组变得与子独立,表明快速适应.
结论:
- *酵母子在自然界中广泛存在,在控制遗传特征方面发挥着重要作用.
- *子有助于表型多样性,可以提供适应优势,扩大进化机会.
- *这些发现挑战了人们对子作为罕见疾病的看法,强调了它们在自然进化中的重要性.
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