主要的空气污染物和心肌梗塞:系统审查和元分析
Hazrije Mustafic1, Patricia Jabre, Christophe Caussin
1Paris Cardiovascular Research Center, University Paris Descartes, INSERM Unit 970, Paris, France. hazrije.mustafic@inserm.fr
JAMA
|February 17, 2012
概括
短期暴露于空气污染,不包括臭氧,显著增加心肌梗塞 (MI) 的风险. 这项研究量化了PM2.5和CO等污染物与心脏病发作的相关性.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 短期暴露于高空气污染水平被怀疑会引发心肌梗塞 (MI).
- 各种空气污染物与MI风险之间的准确关联需要进一步量化.
研究的目的:
- 评估和量化短期暴露于主要空气污染物和MI风险之间的关联.
- 研究的污染物包括臭氧,一氧化碳,二氧化,二氧化硫,PM10和PM2.5.5.
主要方法:
- 2011年11月之前发表的34项研究的系统综述和元分析.
- 在EMBASE,MEDLINE和Cochrane数据库中搜索有关空气污染和MI的研究.
- 使用随机效应模型计算的MI与污染物度增加相关的相对风险 (RRs).
主要成果:
- 发现MI风险与短期暴露于一氧化碳,二氧化,二氧化硫,PM10和PM2.5.5之间的显著关联.
- 臭氧暴露没有显示出与心脏病发作风险增加的统计学意义上的关联 (RR=1.003,P=.36).
- 对于研究的污染物,可归因于人口的分数在0.6%至4.5%之间.
结论:
- 除了臭氧之外,主要的空气污染物与心肌梗塞风险增加有显著的联系.
- 研究结果强调了与环境空气污染相关的短期心血管风险.
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