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在中性pH值下,从聚博洛块共聚合物的聚合体中释放出对单糖体有反应的胰岛素

Hyunkyu Kim¹, Young Ji Kang, Sebyung Kang

¹School of Nano-Bioscience and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), 50 UNIST Road, Ulsan 689-798, Korea.

Journal of the American Chemical Society

|February 21, 2012

概括

研究人员使用boroxole单体和可逆添加碎片和链转移 (RAFT) 聚合物开发了对糖敏感的聚合物. 这些聚合物形成纳米结构,可以在中性pH下对糖水平作出反应,输送胰岛素.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

含醇的聚合物具有独特的结合能力.
控制的激素聚合方法可以实现精确的聚合物合成.
响应刺激的材料对于先进的药物输送系统至关重要.

研究的目的:

合成和表征新型含醇的氨酸单体.
使用可逆添加碎片化和链转移 (RAFT) 聚合,开发对糖有反应性的块共聚物.
研究这些聚合物的自我组装和药物输送能力.

主要方法:

合成含醇的烯单体.
可逆添加碎片化和链转移 (RAFT) 聚合,以创建块共聚合物.
聚合物自组装成纳米结构 (,聚合体) 的表征.
单糖结合试验 (竞争性结合实验).
在体外评估从聚合体中释放的胰岛素.

主要成果:

成功合成了一种含醇的烯单体.
开发出具有受控分子量的聚乙烯博洛 (PBOx) 和PBOx-PEG块共聚合物.
在中性pH酸盐缓冲剂中证明了单糖结合亲和力.
实现了自组装成各种纳米结构,包括聚合体.
展示了聚合体的糖反应分解和在生理pH下控制的胰岛素释放.

结论:

含醇的区块共聚合物是有效的糖反应材料.
飞机聚合允许可调节的纳米结构的形成和刺激响应的行为.
这些聚合体显示出作为胰岛素的智能输送载体的前景,在生理条件下释放胰岛素以响应葡萄糖水平.

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